High blood sugar levels can cause nerve damage or diabetic neuropathy. Sometimes, this damage is not reversible, and can also damage the arteries that carry blood to the legs and feet. In some instances, amputation of a limb may become necessary when the artery is severely damaged. Burning sensations in the limbs is a dangerous symptom, and anyone experiencing this sensation, or pain or signs of infection in a limb should seek immediate medical attention. Quick intervention can prevent serious consequences such as amputation.

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