Some diseases create situations that cause too much or too little hormone production, which can result in hormone resistance in the cells. Cushing's syndrome occurs when there is too much cortisol in the body. Acromegaly is the result of prolonged, excessive production of growth hormones. Hyperthyroidism occurs when the thyroid creates too much hormone. Any of these conditions can provoke diabetes because they upset the natural amount of insulin in the body.

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