There is no main cause of malignant fibrous histiocytomas, although researchers may have identified some related conditions. Receiving radiotherapy for another type of tumor may increase a person's risk. Paget's syndrome, a condition that affects bone cell growth, may also have a link to MFH tumors. A history of other types of sarcoma, such as Werner syndrome or Gardner syndrome, can make getting an MFH tumor more likely.
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