Endometrial cancer develops in the lining of the uterus, and post-menopausal women are most commonly affected. The most frequent symptoms are bleeding not associated with a menstrual period. Women may also experience pelvic pain, frequent urination, and pain during intercourse. To diagnose endometrial cancer, the doctor must order an ultrasound and biopsy, as a pap smear is not reliable to detect this form of cancer. However, pap smears may sometimes show signs of the abnormal uterine lining and follow up tests may help detect endometrial cancer.

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