As this medical term clearly indicates the surgeon, in this case, needs to remove the entire pancreas. One of the situations where this could be necessary is when the cancer is positioned in a way that leaves the surgeon no alternative. Although the other surgical procedures are major undertakings with long-lasting effects, the total pancreatectomy has the most severe consequences. The patient is left with diabetes for the remainder of their life, and they also need to take enzymes to help them to digest food. Since the surgeon also removes the spleen the patient is also going to need regular doses of antibiotics and vaccinations.

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