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15. Bone Pain

Bone pain may cause discomfort in the upper thighs, lower back, or hip. Advanced prostate cancer often spreads to the bone; one study found that about 90 percent of men who died with metastasized prostate cancer had bone metastases. Prostate cancer cells tend to invade the ribs, spine, and pelvis, which have more red marrow than other bones.

Shoulder pain manusapon kasosod / Getty Images

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