10 Symptoms Indicating Pancreatic Cancer

6. Unusual Blood Clots

In some cases, the first sign of pancreatic cancer is a blood clot, particularly in a large vein of the leg (deep vein thrombosis or DVT). Symptoms may include swelling, redness, pain, or warmth in the affected limb. A clot can also break off and travel to the lungs, causing shortness of breath or chest pain—a medical emergency known as pulmonary embolism. If these symptoms occur without a clear cause, it’s important to seek immediate evaluation.