From persistent fatigue to an enlarged spleen, these are the key signs worth knowing
The people affected by myelofibrosis feel tired and exhausted all the time. This feeling is present even with no or minimal effort. As a direct result of their disease, they may start to lose their appetite and eat less or refuse to eat. This will may make them lose weight. The combination of fatigue, appetite loss, and weight loss will lead to a type of weakness that may progress to wasting of the body that is common in severe chronic disease. This is called cachexia, and it is also common in patients who have other types of cancers.

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