From persistent fatigue to an enlarged spleen, these are the key signs worth knowing
The fibrosis of parts of the bone marrow decreases its production of platelets as well. Platelets play a major role in forming clots and stopping the bleeding. The low number of platelets is scientifically termed "thrombocytopenia." It will lead to petechiae and bleeding from the gums, nose and under the skin. Petechiae are small red spots on the skin or mucous membrane resulting from bleeding of a small capillary vessel. Small petechiae can group together to form a larger purple or blue spot called ecchymoses. Myelofibrosis will also experience bleeding from minor trauma and an increase in the time needed so that the bleeding stops.

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