Multiple myeloma also causes gastrointestinal issues, which can lead to symptoms and signs such as nausea, vomiting, diarrhea, and constipation. These symptoms are not indicative of multiple myeloma alone, however, so when they occur repeatedly prior to a diagnosis, it is important that a doctor begin investigating the cause. In some cases, these symptoms may be due to medications used to treat multiple myeloma rather than the disease itself.

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