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2. Anemia

Anemia is a low red blood cell count or a lack of hemoglobin. In general, people with this condition experience fatigue and skin pallor. People with multiple myeloma often present with this symptom because the cancer damages the bone marrow, where red blood cells are created. According to the International Myeloma Foundation, 60 to 70% of people with multiple myeloma already have anemia at the time of diagnosis.

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