Though uncommon, back pain is a symptom of esophageal cancer. It most often occurs when tumors spread to the pericardium and the mediastinum. The pericardium sits around the heart, providing both protection and lubrication. It also connects the heart to the mediastinum, the central compartment that contains the organ. If cancer spreads to either of these structures, the pain can radiate laterally, presenting as back pain.

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