14 Signs of Multiple Myeloma

7. Muscle pain or numbness

Depending on where the plasmacytomas are located, you may experience localized muscle pain, numbness or even weakness. If the tumors are located near the spine, it may cause these same issues in other parts of your body as well. Tumors can compress nerves, and they can also put pressure on muscles and other tissues in the body. These changes can be very uncomfortable or even painful, especially if the tumor is left untreated and continues to grow. You may also feel a pins-and-needles sensation, or the muscle may seem weaker than usual during use. In some cases, this is one of the first signs that a plasmacytoma or other tumor has formed.