Experiencing weakness, tiredness, or lightheadedness can be another sign of colon cancer. Colon cancer sometimes causes bleeding into the intestines. Over time, chronic bleeding results in anemia and symptoms of weakness and fatigue due to iron deficiency. Cancer itself can also cause fatigue, even if there isn't a lot of bleeding. This is due to the release of special proteins into the blood or consumption of the body's energy by the growing cancer. Many types of cancer can cause tiredness, so it is not specific to colon cancer.

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