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2. Causes of PSP

Researchers theorize that several genetic and environmental factors contribute to progressive supranuclear palsy, though they have not yet identified all the relevant genes. In some cases, PSP is associated with a mutation in the MAPT gene, which provides instructions for making the tau protein. Genetic changes on chromosomes 1 and 11 are also associated with PSP. People diagnosed with PSP rarely have a family history of the illness, which makes it even more difficult to identify causative genes and other factors.

research, MAPT gene, chromosome, family nicolas_ / Getty Images
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