Researchers theorize that several genetic and environmental factors contribute to progressive supranuclear palsy, though they have not yet identified all the relevant genes. In some cases, PSP is associated with a mutation in the MAPT gene, which provides instructions for making the tau protein. Genetic changes on chromosomes 1 and 11 are also associated with PSP. People diagnosed with PSP rarely have a family history of the illness, which makes it even more difficult to identify causative genes and other factors.
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