When cancer cells break down, they release various substances into the blood. Occasionally, this break down occurs so rapidly that the kidneys cannot filter all of the new substances, and the individual develops tumor lysis syndrome (TLS). Large-scale cell breakdown and death leads to high levels of various nucleic acids. Among them, purines become uric acid through the normal process. However, because the concentration is so much higher, the body cannot excrete uric acid in the urine. This results in a dramatic increase of urate crystals in the blood, kidneys, and joints.

This site offers information designed for educational purposes only. You should not rely on any information on this site as a substitute for professional medical advice, diagnosis, treatment, or as a substitute for, professional counseling care, advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional.