Granulocytes are a type of white blood cell that includes neutrophils. Granulocyte-macrophage colony-stimulating factor, GM-CSF, is a protein that spurs white blood cell growth. It also inhibits mature neutrophil migration as part of its goal to improve the body's defense against infection. GCSF, Granulocyte colony-stimulating factor, is a protein that stimulates the growth of granulocytes and stem cells in the bone marrow. Research shows that because those with Felty's experience recurring and serious infections, including pulmonary and skin infections, these two types of granulocyte-based therapies can improve neutropenia and immunity.

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