Sexually active men aged 20-40 is the most common demographic diagnosed with Reiter's syndrome. It is also associated with HIV. Three percent of men with a sexually transmitted disease will develop Reiter's. Women and children who develop Reiter's syndrome generally acquire the intestinal form of the disease and have milder symptoms. Most people who experience the triggering infections do not develop Reiter's syndrome, perhaps because they lack the gene HLA-B27, which is present in 94 percent of people with the condition.

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