Because T cells mature in the thymus, it has direct links to immunodeficiency and autoimmune diseases. Additionally, tumors may develop from the thymic epithelial cells. Known as thymomas, these tumors most often occur in people over 40. In some instances, thymomas cause the immune system to attack its own cells and tissues. Cysts can also develop in or around the thymus, though these are usually asymptomatic.

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