In extreme cases of gastroesophageal reflux disease, tissue similar to the intestinal lining replaces the tissue normally present in the mouth and esophagus. This is a condition experts call Barrett’s esophagus. People with this condition have a higher chance of developing esophageal cancer. Beyond this, they experience only symptoms similar to gastroesophageal reflux disease. There are cases where people without a reflux disease or disorder develop Barrett’s esophagus, and the cause is unknown.

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