Causes of Stomach Pain

11. Allergies

The immune response to allergies, especially food allergies, can result in stomach pain. Even the smallest amount of a problematic food could trigger mild to severe symptoms when the offending ingredient finds its way to the intestines. The result is a flood of immunoglobulin E, IgE, antibodies, and histamine into the gastrointestinal tract. Histamine irritates the digestive tract, leading to stomach cramps and pain. Food allergies can also manifest with other symptoms, including itching, skin rash, difficulty breathing, and chest pain.