Flare-ups of granuloma annularae that result in skin lesions usually enter spontaneous remission within a few weeks. This means the lesions disappear without medical intervention, although in many instances they reappear again. Most people with localized GA stop experiencing flare-ups in fewer than five years. The generalized form often heals spontaneously and reappears months or years later. Approximately 25% of non-localized GA cases affect people for more than five years and sometimes last longer than ten years.

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