Although many people associate gangrene exclusively with diabetes, several factors can cause this condition. Any event that cuts off blood and oxygen supply to organs or tissues elevates the risk of gangrene. The nutrients in blood and oxygen feed the body's cells and boost the immune system to fight infection. After being cut off from blood and oxygen for a time, the tissues start to decay. This can also happen following trauma such as a gunshot wound or other injury. The bacteria that form after an injury can invade damaged tissue and cause gangrene. The same is true with a bacterial infection, especially if the individual is unaware that it exists. The infection eventually kills the tissue and leads to gangrene, if untreated.
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