Dupuytren's contracture specifically affects the hands. One of the most common symptoms is being unable to lay the palm flat against a table. This condition causes small nodules to form in the palm. These lumps may be painful at first, but pain generally eases over time. The nodules thicken and tighten, which causes thick bands of tissue to form under the skin, pulling the fingers forward. The exact cause is unknown, but Dupuytren's contracture is believed to be hereditary, particularly in those with Northern European heritage. It usually starts in middle age and affects men more than women.

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