Ehlers-Danlos Syndrome may result in early and accelerated osteoarthritis or joint "wear and tear" due to joint instability. In addition to joint pain, patients may also have increased stress on the muscles and ligaments around a joint as well as nerve-related pain. It has been shown that in such chronic pain states, the pain-sensing system in the spinal cord and brain, does not function properly. As a consequence, residual pain signals from a site of a healed injury in EDS may become amplified, and this can be extremely disabling from physical, emotional, and social perspectives.

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