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5. Kyphoscoliosis

Skeletal deformities may be apparent at birth, including abnormal sideways curvature of the spine (congenital scoliosis) that becomes progressively severe and is generally associated with diminished muscle tone (hypotonia). In children with the disorder, severe hypotonia may cause delays in the acquisition of certain motor skills, and affected adults may lose the ability to walk by the second or third decade of life.

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