A doctor may recommend you treat urticaria with antihistamine medication. Patients who experience frequent breakouts may need to regularly administer antihistamines to prevent recurring reactions. Calamine lotion can be used to topically treat itching caused by hives, while over the counter pain relievers are usually enough to help with any pain. In severe cases, a doctor may administer injectable medications to combat the outbreak more effectively and quickly. These cases are medical emergencies and usually occur when the hives develop in the mouth, throat, or lungs.

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