Splenohepatomegaly happens when both the liver and spleen are enlarged, which could signify fatty liver disease. As an increasing amount of fat is stored in the liver, the organ's expanding weight and size cause it to push against surrounding tissue. Both the spleen and the liver play a key role in detoxifying the body. When they do not function properly, the risk of infection significantly increases. The enlargement of the spleen and liver may occur together, or separately.
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