Various types of liver disease can affect the nails. One study that set out to record new nail abnormalities in patients with liver disease found that 68 percent of study participants in the patient group had nail changes, compared to 35 percent in the control group.
The most common was a nail infection called onychomycosis. Other changes included longitudinal grooves, brittle nails, finger clubbing, and nails that were thick, deformed, or discolored.

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