10 Causes of Elevated Liver Enzymes

6. Mononucleosis

Mononucleosis, also called mono, the "kissing disease," and glandular fever, is most often caused by the Epstein-Barr Virus (EBV). In a minority of the cases, the cytomegalovirus (CMV) is the cause. In childhood, the disease may cause few to no symptoms. When the disease infects adults, it can result in fever, sore throat, enlarged lymph nodes, and fatigue. Diagnosis can be confirmed with a blood test. In many cases of mono, the liver and spleen become swollen as well. Any time the liver is enlarged or inflamed, liver enzyme levels increase. Mononucleosis usually resolves in three to six weeks, with fatigue sometimes lasting longer.