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10. Historical Significance of Uremia

In the early 1800s, researchers discovered that the kidneys excrete urea. At the same time, this substance was identified as the cause of specific disorders and toxicity in the body. Urea crystals were the first substance to be synthesized and replicated in a lab, by oxidating proteins. This process led Thomas Dutrochet to discover dialysis in 1850. The method of dialysis involves separating smaller urea particles from normal healthy cells through a semipermeable membrane.

Urea crystal from human body jonnysek / Getty Images
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