As the kidneys fail to filter out waste and other products, toxins begin to accumulate in the blood. This can have many effects, most of which take time to develop before becoming noticeable. One of the first to become noteworthy, however, is a general sense of tiredness and persistent fatigue. In some cases, this may come with muscle weakness.
With time, this fatigue can become so severe that formerly easy daily activities become difficult or nearly impossible.

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