When the spaces between the renal tubules that form urine swell and become inflamed, it can lead to a bladder infection. Diagnosed as interstitial nephritis which is either an acute or chronic infection. An allergic reaction to antibiotics, anti-inflammatory drugs or pain relievers causes nearly all of the cases of swollen tubes. The symptoms mirror those of a kidney infection which include fever and chills, bloating, high blood pressure, water retention, internal swelling. The swelling of the interstitium can make it difficult to urinate. There may be blood in the urine or significantly less urine than usual.

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