Toe and legs spasms can quickly graduate from annoying to debilitating the more frequently they occur. Arteriosclerosis, sometimes referred to as atherosclerosis, can contribute to painful cramps. This condition occurs when fats, cholesterol and other substances build up in artery walls, narrowing the passageways and restricting nutrient-rich blood flow to the extremities. The condition often results in cramp-like pains in the legs and feet during exercise, relieved only when the physical activity stops.

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