A malfunctioning pancreas can cause yellow eyes and skin in two ways. Pancreatitis, an inflammatory disease, can result in edema or swelling that compresses part of the duct. This results in hyperbilirubinemia, which is characterized by extremely high bilirubin levels. In the case of pancreatic cancer, the tumor can also block the bile duct, and symptoms, such as severe, widespread itchiness, usually prompt people to seek a diagnosis.

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