Some people with autoimmune diseases find that these conditions were originally triggered by a prescribed medication. This is referred to as drug-induced autoimmune diseases, and it occurs more with some diseases than others. Lupus is the most commonly triggered disease. For a drug-induced autoimmune disease to occur, a patient must already have the genes that cause the disease. Certain types of antibiotics, anticonvulsants, and heart medications, along with many others, have been linked to this phenomenon. Researchers estimate that nearly 100 different medications can cause drug-induced autoimmune disease.

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