Children with Rett Syndrome typically lose their ability to speak between ages 1 and 4. This is the beginning of a communication shutdown in their bodies. The MECP2 gene, which is responsible for movement as well as cognitive, sensory, emotional, motor and autonomic skills, affects their brain and the ability to create the right sounds with their mouths and vocal cords. Rett syndrome patients tend to develop some non-verbal communication skills over time.

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