Magnesium deficiencies can cause extreme exhaustion and constant tiredness because the nutrient has a critical role in regulating energy levels. The mineral's interaction with more than 300 enzyme systems means a lack of magnesium interrupts protein synthesis, muscle and nerve functions, and blood pressure, all of which are essential to energy production. In addition, magnesium deficiency is linked with potassium deficiency in up to 50% of cases. Low potassium also causes fatigue and weakness.

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