An enlarged spleen can irritate the diaphragm, which causes hiccups. Pain may radiate to the back and shoulder blade. There is compression to the stomach, causing indigestion, discomfort, or a feeling of fullness after eating even a small amount of food. The doctor will review symptoms and perform a physical exam; palpitation cannot identify a normal spleen, but in most cases, the doctor can feel an enlarged one. Ultrasounds, abdominal CTs, x-rays, and MRIs can diagnose spleen issues and pain.

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