Both infections and injuries cause an enlarged spleen, and there may be no warning symptoms. As the spleen increases in size, the risk of a spleen rupture also increases. Sharp pain in the left side could indicate the spleen is enlarged and pressing against the stomach, especially if the person also experiences nausea or unexplained weight loss. Enlarged spleens are a symptom of various illnesses, including chronic or slow-growing leukemia, anemia, Hodgkin’s disease, mononucleosis, malaria, and juvenile idiopathic arthritis.

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