Doctors may prescribe medications for reflux if lifestyle changes do not work. These medications either decrease the amount of acid in the stomach or increase motility. Several types of mediation can work for reflux. Antacids are often used to treat intermittent and infrequent reflux; over the long-term, though, they can increase acid production and worsen the problem.
Other medications include histamine blockers and proton pump inhibitors, which suppress acid production and may help heal esophageal erosions. Prokinetic agents enhance the activity of the smooth muscle in the GI tract to speed up digestion and may be used in conjunction with drugs that inhibit acid production.

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