Homemade weed killers get rid of poison ivy with repeated applications. Add 1-cup of salt, 2-tablespoons of lemon juice, and 1-teaspoon of liquid dish soap to a gallon of white vinegar. Pour the vinegar mixture into a spray bottle, and shake the bottle vigorously to dissolve the salt. Wear gloves, pants, and a long-sleeved shirt while spraying poison ivy plants. Wear goggles or safety glasses to keep the solution or poison ivy resin away from the eyes. Spray the poison ivy plant thoroughly. Try to coat every leaf and stem. Pour some of the solution on the ground around the plant to kill roots.

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