Research has also identified differences in brain structure as a possible cause of transgender identity. A 2014 study found differences in the white matter tracts in the brain between cisgender (agreement between gender and sex) and transgender men and women. These tracts are influenced by hormones during late prenatal and early postnatal development. The study used MRI imaging to examine the microstructure of white matter and identified widespread differences between the study groups in almost all white matter tracts.

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