Understanding the Causes and Symptoms of Biotin Deficiency

8. Biotinidase Deficiency

There are two types of biotinidase deficiency, a genetic disorder that prevents the body from recycling biotin: partial and profound. Partial biotinidase deficiency is the milder form, causing symptoms such as skin problems, alopecia, and candidiasis. The profound type prompts these symptoms, affects balance and causes developmental delays and seizures. One in 61,000 people has a partial deficiency, while one in 140,000 has the more severe form. Left undiagnosed, biotin and biotinidase deficiencies can be life-threatening.