Understanding the Causes and Symptoms of Biotin Deficiency

3. Phenylketonuria

Phenylketonuria is an inherited genetic disorder that renders the body incapable of metabolizing the essential amino acid phenylalanine. As a result, the amino acid builds up in the blood to toxic levels and causes intellectual disability, mental disorders, and even heart problems. Studies show that in children with phenylketonuria, the biotin recycling process is impaired, resulting in lower biotinidase activity and seborrheic dermatitis, a common skin condition.