Many medications and supplements, including niacin, can cause nausea, vomiting, diarrhea, and heartburn, especially when taken for the first time. These side effects usually subside in a few days or weeks. Niacin supplements also have the potential to cause itchy or dry skin, headaches, sweating, chills, and insomnia. Although these side effects are normal, persistent or severe symptoms may indicate a more serious problem. Consult a doctor immediately if side effects are accompanied by abdominal pain or jaundice. This yellow tinge to the skin or whites of the eyes can indicate a more serious issue.

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