Magnesium toxicity can affect parts of the brain that control mood and regulate stress. As a result, people who have too much magnesium in their system might feel depressed.
Hypermagnesemia can make people feel tired, overwhelmed, numb, unhappy, disinterested, or vaguely unwell. Magnesium can also affect a person's circadian rhythm, making it difficult to sleep and intensifying symptoms in people with depression.

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