Niacin, also known as vitamin B3, helps cells in the immune system fight infection. In the skin, these are called Langerhans cells. Niacin helps these immune cells function properly, but foods high in niacin can trigger adverse reactions in some people. Foods high in niacin, like tuna, encourage Langerhans cells to release a compound that increases redness and swelling in the skin. Researchers think this may be the primary molecular pathway that causes flushing in rosacea.

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