The first and least harmful symptom of secondary syphilis is a rash, which usually appears on the soles of the feet and hands. The rash looks somewhat like the previous painless spots, but soon begins to itch. The itching can continue for a long time. Rashes occur on the skin mainly due to the activity of the lymphatic system, which inflames the surrounding epidermis as it combats the disease.

This site offers information designed for educational purposes only. You should not rely on any information on this site as a substitute for professional medical advice, diagnosis, treatment, or as a substitute for, professional counseling care, advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional.