The most common treatment for exocrine pancreatic insufficiency is pancreatic enzyme replacement therapy (PERT). Prescription medications replace the enzymes the pancreas is not producing. These need to be taken during meals to ensure the enzymes work at the right time. Some people require additional medicines to reduce acid in the stomach, an excess of which may destroy the enzymes from PERT before they can work. Painkillers can alleviate physical discomfort.

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